Ultra-Rapid Pain Relief From Your Migraine Attacks is Possible!

Why wait two hours or more for pain relief when Tosymra can provide relief in as little as 10 minutes.1-3

Ultra-Rapid Pain Relief From Your Migraine Attacks is Possible!

Why wait two hours or more for pain relief when Tosymra can provide relief for some patients in as little as 10 minutes.

No Two Migraines are the Same

Different migraines require different approaches. Migraine is a debilitating disease that can be further complicated when certain symptoms are present.

If you suffer from any of the following migraines, Tosymra may be able to help:

Tosymra may also help with:

Comorbid gastroparesis or patients using GLP-1 agonists.6,7

GLP-1 agonists delay gastric emptying, which may alter the absorption and efficacy of orally administered drugs.7

Tosymra Nasal Device

Why Choose Tosymra?

Fast and Powerful.1,8

Well-Established and Tolerable.9,10

Convenient to Carry and Easy-to-Use.

Tosymra is a prescription medicine used to treat acute migraine headaches with or without aura in adults 18 years of age and older who have been diagnosed with migraine.

Fast and Powerful

Intravail helps deliver the sumatriptan into the nasal mucosa providing efficiency bio-equivalent to 4mg subcutaneous (SC) sumatriptan injection.9-11

Tosymra Tmax (peak plasma concentration) was observed at 10 minutes.8

8X faster than sumatriptan nasal spray without Intravail.8

5 minutes faster than (SC) sumatriptan injection.8

Well-Established and Tolerable

Tosymra nasal spray 10 mg is ½ the dose of 20 mg Imitrex Nasal Spray.1,12

Millions of prescriptions of nasal sumatriptan have been prescribed to patients living with migraine since 1992.13

In a clinical trial, no subjects reported bad taste (dysgeusia) as a reason for discontinuation.14

2.9% of all doses were associated with a triptan-related side effects (none were severe).14,15

Convenient to Carry and Easy-to-Use

Simple, three-step process

Please see Important Safety Information; full Prescribing Information, including Patient Information; and Instructions for Use.

Tosymra is affordable — get it for as little as $0*

A prescription can be sent to most traditional pharmacies, but BlinkRx offers a digital alternative.

With BlinkRx, you can expect:

Low price

BlinkRx works with your insurance. If you are commercially insured and eligible, it applies available savings to your prescription.*

Simple experience

BlinkRx will send you a text with the lowest price available at BlinkRx. You can pay for your prescription online or over the phone.

Prescription support

The BlinkRx team has pharmacists to help answer questions and help with refills and reminders.

Free, fast delivery

BlinkRx will deliver your Tosymra prescription for free.

Low price

BlinkRx works with your insurance. If you are commercially insured and eligible, it applies available savings to your prescription.*

Simple experience

BlinkRx will send you a text with the lowest price available at BlinkRx. You can pay for your prescription online or over the phone.

Prescription support

The BlinkRx team has pharmacists to help answer questions and help with refills and reminders.

Free, fast delivery

BlinkRx will deliver your Tosymra prescription for free.

*Restrictions and quantity limits apply. Click to view complete program terms and conditions. Medicare, Medicaid, and other federal and state healthcare program patients are not eligible.

Use this printable guide to discuss the benefits of Tosymra with your healthcare team.

References:
1) Tosymra [package insert]. Chatham, NJ: Tonix Medicines, Inc, 2023.  2) Mathew NT, et al. Dose ranging efficacy and safety of subcutaneous sumatriptan in the acute treatment of migraine. US Sumatriptan Research Group. Arch Neurol. 1992;49(12):1271-1276.  3) Wendt J, et al. A randomized, double-blind, placebo-controlled trial of the efficacy and tolerability of a 4-mg dose of subcutaneous sumatriptan for the treatment of acute migraine attacks in adults. Clinical Therapeutics. 2006;28(4):517-526.  4) Top 10 migraine triggers and how to deal with them. American Migraine Foundation. https://americanmigrainefoundation.org/resource-library/top-10-migrainetriggers-and-how-todeal-withthem/. Published July 27, 2017. Accessed April 2024.  5) Lipton RB, et al. Headache. 2019 Sep;59(8):1310-1323.  6) Newman LC. Headache. 2013 Jun;53 Suppl 1:11-16.  7) In brief: Gi effects of GLP-1 receptor agonists: The Medical Letter Inc.. The Medical Letter Inc. (n.d.). https://secure.medicalletter.org/TML-article-1690e.  8) Munjal S, et al. Headache. 2016;56(9):1455-1465.   9) Maggio ET. J Excipients and Food Chem. 2014;5(2):100-112.  10) Maggio ET. Expert Opin Drug Deliv. 2006;3(4):529-539. 11) Maggio ET, et al. Drug Deliv Transl Res.2013;3(1):16-25.  11. Madden S, et al. Pharmaceutics 2023;15: 2119.  12) IMITREX Nasal [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2020.  13) Pharmaco-economic data was obtained from the national Symphony Health prescription database. The database captures prescriptions from >307 million individuals, >1.98 million subscribers, >18,000 health plans as well as 85% of retail, 74% of mail order and 73% of specialty pharmacies, respectively.  14) Munjal S, et al. The Journal of Headache and Pain. 2017;18(1):31. 15) Data on file, Tonix Medicines: 2024.
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Do not take Tosymra® if you have hemiplegic migraines or basilar migraines or to treat cluster headache.

IMPORTANT SAFETY INFORMATION
Tosymra can cause serious side effects, including heart attack and other heart problems, which may lead to death. Stop use and get emergency medical help if you have any signs of heart attack:

  • discomfort in the center of your chest that lasts for more than a few minutes or goes away and comes back
  • severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
  • pain or discomfort in your arms, back, neck, jaw or stomach
  • shortness of breath with or without chest discomfort
  • breaking out in a cold sweat
  • nausea or vomiting
  • feeling lightheaded

Tosymra is not for people with risk factors for heart disease (high blood pressure or cholesterol, smoking, overweight, diabetes, family history of heart disease) unless a heart exam shows no problem.

Do not use Tosymra if you have:

  • history of heart problems
  • narrowing of blood vessels to your legs, arms, stomach, or kidney (peripheral vascular disease)
  • uncontrolled high blood pressure
  • hemiplegic or basilar migraines. If you are not sure if you have these, ask your provider.
  • had a stroke, transient ischemic attacks (TIAs), or problems with blood circulation
  • severe liver problems
  • taken any of the following medicines in the last 24 hours: almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, ergotamines, or dihydroergotamine. Ask your provider for a list of these medicines if you are not sure.
  • are taking certain antidepressants, known as monoamine oxidase (MAO)-A inhibitors or it has been 2 weeks or less since you stopped taking a MAO-A inhibitor. Ask your provider for a list of these medicines if you are not sure.
  • an allergy to sumatriptan or any of the components of Zembrace or Tosymra

Tell your provider about all of your medical conditions and medicines you take, including vitamins and supplements.

Tosymra can cause dizziness, weakness, or drowsiness. If so, do not drive a car, use machinery, or do anything where you need to be alert.

Tosymra may cause serious side effects including:

  • changes in color or sensation in your fingers and toes
  • sudden or severe stomach pain, stomach pain after meals, weight loss, nausea or vomiting, constipation or diarrhea, bloody diarrhea, fever
  • cramping and pain in your legs or hips; feeling of heaviness or tightness in your leg muscles; burning or aching pain in your feet or toes while resting; numbness, tingling, or weakness in your legs; cold feeling or color changes in one or both legs or feet
  • increased blood pressure including a sudden severe increase even if you have no history of high blood pressure
  • medication overuse headaches from using migraine medicine for 10 or more days each month. If your headaches get worse, call your provider.
  • serotonin syndrome, a rare but serious problem that can happen in people using Zembrace or Tosymra, especially when used with anti-depressant medicines called SSRIs or SNRIs. Call your provider right away if you have: mental changes such as seeing things that are not there (hallucinations), agitation, or coma; fast heartbeat; changes in blood pressure; high body temperature; tight muscles; or trouble walking.
  • hives (itchy bumps); swelling of your tongue, mouth, or throat
  • seizures even in people who have never had seizures before

The most common side effects of Tosymra include: tingling dizziness; feeling warm or hot, burning feeling, feeling of heaviness, feeling of pressure, flushing, feeling of tightness, numbness, application site (nasal) reactions, abnormal taste, and throat irritation.

Tell your provider if you have any side effect that bothers you or does not go away. These are not all the possible side effects of Tosymra. For more information, ask your provider.

This is the most important information to know about Tosymra but is not comprehensive. For more information, talk to your provider and read the Patient Information and Instructions for Use. You can also visit https://www.tonixpharma.com or call 1-888-869-7633.

You are encouraged to report adverse effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.