While sitting upright, gently blow the nose. Press one nostril with a finger to keep it closed.
While sitting upright, gently blow the nose. Press one nostril with a finger to keep it closed.
Hold the device upright, insert half of the spray nozzle into the open nostril, angling it slightly outward toward the outside of the nostril (not straight up).
Hold the device upright, insert half of the spray nozzle into the open nostril, angling it slightly outward toward the outside of the nostril (not straight up).
While keeping the device in the nose, tilt head back slightly. This will allow the medicine to go into the nasal passage without dripping out.
Slowly breathe through the nose and press the device plunger upward to release the spray. While keeping the head upright, gently breathe in through the nose and breathe out through the mouth for 10 to 20 seconds.
While keeping the device in the nose, tilt head back slightly. This will allow the medicine to go into the nasal passage without dripping out.
Slowly breathe through the nose and press the device plunger upward to release the spray. While keeping the head upright, gently breathe in through the nose and breathe out through the mouth for 10 to 20 seconds.
Please see Important Safety Information; full Prescribing Information, including Patient Information; and Instructions for Use.
Tosymra is formulated with Intravail technology to help the medication be absorbed into the bloodstream so it can work quickly. It works as fast as an injection, providing migraine pain relief in as little as 10 minutes for some patients with just one spray (13% vs. 5% for placebo).1-3
Efficacy of Tosymra is based on relative bioavailability to subcutaneous sumatriptan at a dose of 4 mg. In a clinical study, this dose of sumatriptan resulted in 57% of patients achieving pain relief at 2 hours vs. 21% for placebo.
Do not take Tosymra® if you have hemiplegic migraines or basilar migraines or to treat cluster headache.
IMPORTANT SAFETY INFORMATION
Tosymra can cause serious side effects, including heart attack and other heart problems, which may lead to death. Stop use and get emergency medical help if you have any signs of heart attack:
Tosymra is not for people with risk factors for heart disease (high blood pressure or cholesterol, smoking, overweight, diabetes, family history of heart disease) unless a heart exam shows no problem.
Do not use Tosymra if you have:
Tell your provider about all of your medical conditions and medicines you take, including vitamins and supplements.
Tosymra can cause dizziness, weakness, or drowsiness. If so, do not drive a car, use machinery, or do anything where you need to be alert.
Tosymra may cause serious side effects including:
The most common side effects of Tosymra include: tingling dizziness; feeling warm or hot, burning feeling, feeling of heaviness, feeling of pressure, flushing, feeling of tightness, numbness, application site (nasal) reactions, abnormal taste, and throat irritation.
Tell your provider if you have any side effect that bothers you or does not go away. These are not all the possible side effects of Tosymra. For more information, ask your provider.
This is the most important information to know about Tosymra but is not comprehensive. For more information, talk to your provider and read the Patient Information and Instructions for Use. You can also visit https://www.tonixpharma.com or call 1-888-869-7633.
You are encouraged to report adverse effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.